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World Keratoconus
      Congress


 DRY EYE SYNDROME IN
KERATOCONUS PATIENTS


           Guilherme Ferrara
Introduction

             Changes on the ocular surface
•   High keratometric values
•   Scratching & Atopy
•   Contact lens
•   Corneal sensation / Innervation
                   Changes in tears
                    Inflammation




       Dry eye syndrome & Keratoconus
Introduction

             Changes on the ocular surface
•   High keratometric values
•   Scratching & Atopy
•   Contact lens
•   Corneal sensation / Innervation
                   Changes in tears
                    Inflammation




       Dry eye syndrome & Keratoconus
Break up Time



0 seconds   1 second          2 seconds   3 seconds




4 seconds   5 seconds         6 seconds   16 seconds




                        Must be higher
                        than blink
                        frequency.
Introduction


             Changes on the ocular surface
•   High keratometric values
•   Scratching & Atopy
•   Contact lens
•   Corneal sensation / Innervation
                   Changes in tears
                    Inflammation



       Dry eye syndrome & Keratoconus
Introduction


             Changes on the ocular surface
•   High keratometric values
•   Scratching & Atopy
•   Contact lens
•   Corneal sensation / Inervation
                   Changes in tears
                     Inflamation



       Dry eye syndrome & Keratoconus
Blepharitis and Contact Lens
    Evaporative Dry Eye




Dry eye syndrome & Keratoconus
Introduction


             Changes on the ocular surface
•   High keratometric values
•   Scratching & Atopy
•   Contact lens
•   Corneal sensation / Inervation
                   Changes in tears
                     Inflamation



       Dry eye syndrome & Keratoconus
Cornea and Conjunctiva staining
Dry eye syndrome & Keratoconus
Lipid component: Osmolarity
                                368 mOsm /l
303 mOsm/l     368 mOsm /l
                                 tratamiento
Hiperosmolarity


                        368 mOsm /l




303 mOsm /l



Dry eye syndrome & Keratoconus
Lachrymal Functional Unit
       Innervation




                             Aferente
                             Eferente Parasimpático
                             Eferente Simpático




Dry eye syndrome & Keratoconus
Psicometría
                       Escala Visual Analógica
  1. Frecuencia de los síntomas: Por favor, ponga una X en la línea para indicar lo
     frecuente que normalmente siente sus ojos secos y / o irritados

      Raramente _______________________________________Siempre



   2. Gravedad de los síntomas: Por favor, ponga una X en la línea para indicar la
       gravedad que normalmente siente sus ojos secos y / o irritados

      Muy leve_______________________________________Muy Grave


                                         SANDE: Symptom Assessment iN Dry Eye
Schaumberg DA et al. Development and Validation of a Short Global Dry Eye
Symptom Index
The Ocular Surface 2007;5:50-57


          Dry eye syndrome & Keratoconus
Psicometría
                       Escala Visual Analógica
  1. Frecuencia de los síntomas: Por favor, ponga una X en la línea para indicar lo
     frecuente que normalmente siente sus ojos secos y / o irritados comparado
     con su visita de hace dos meses

      Raramente _______________________________________Siempre

                                    Ultima visita
  2. Gravedad de los síntomas: Por favor, ponga una X en la línea para indicar la
      gravedad que normalmente siente sus ojos secos y / o irritados comparado
      con su visita de hace dos meses

      Muy leve_______________________________________Muy Grave

                                    Ultima Visita
Schaumberg DA et al. Development and Validation of a Short Global Dry Eye
Symptom Index
The Ocular Surface 2007;5:50-57


          Dry eye syndrome & Keratoconus
Treatment
Multidisciplinary approach. Multiple and
Protracted
Avoid risk factors
  Scratch
  Contact lens Hygiene
Preventive treatment
  Education of the patient
  Avoid tear evaporation
Anti-inflammatory if evidence of inflammation


     Dry eye syndrome & Keratoconus
Treatment

Intra corneal ring segments
  Improvement of keratometry
  Reduction of dry eye symptoms
  Reduction of scratch
  Reduction of use of the contact lens




     Dry eye syndrome & Keratoconus
Conclusions
• Keratoconus patients are more susceptible to
  develop a dry eye syndrome
• BUT & mucus thin layer healthy are good
  markers of a normal function of the
  epithelium of the ocular surface.
• Treatment Protocol of DES in Keratoconus
  patients.



     Dry eye syndrome & Keratoconus
Thank you
Keratoconus and Dry Eye

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Keratoconus and Dry Eye

  • 1.
  • 2. World Keratoconus Congress DRY EYE SYNDROME IN KERATOCONUS PATIENTS Guilherme Ferrara
  • 3. Introduction Changes on the ocular surface • High keratometric values • Scratching & Atopy • Contact lens • Corneal sensation / Innervation Changes in tears Inflammation Dry eye syndrome & Keratoconus
  • 4. Introduction Changes on the ocular surface • High keratometric values • Scratching & Atopy • Contact lens • Corneal sensation / Innervation Changes in tears Inflammation Dry eye syndrome & Keratoconus
  • 5. Break up Time 0 seconds 1 second 2 seconds 3 seconds 4 seconds 5 seconds 6 seconds 16 seconds Must be higher than blink frequency.
  • 6. Introduction Changes on the ocular surface • High keratometric values • Scratching & Atopy • Contact lens • Corneal sensation / Innervation Changes in tears Inflammation Dry eye syndrome & Keratoconus
  • 7. Introduction Changes on the ocular surface • High keratometric values • Scratching & Atopy • Contact lens • Corneal sensation / Inervation Changes in tears Inflamation Dry eye syndrome & Keratoconus
  • 8. Blepharitis and Contact Lens Evaporative Dry Eye Dry eye syndrome & Keratoconus
  • 9. Introduction Changes on the ocular surface • High keratometric values • Scratching & Atopy • Contact lens • Corneal sensation / Inervation Changes in tears Inflamation Dry eye syndrome & Keratoconus
  • 11. Dry eye syndrome & Keratoconus
  • 12. Lipid component: Osmolarity 368 mOsm /l 303 mOsm/l 368 mOsm /l tratamiento
  • 13. Hiperosmolarity 368 mOsm /l 303 mOsm /l Dry eye syndrome & Keratoconus
  • 14. Lachrymal Functional Unit Innervation Aferente Eferente Parasimpático Eferente Simpático Dry eye syndrome & Keratoconus
  • 15. Psicometría Escala Visual Analógica 1. Frecuencia de los síntomas: Por favor, ponga una X en la línea para indicar lo frecuente que normalmente siente sus ojos secos y / o irritados Raramente _______________________________________Siempre 2. Gravedad de los síntomas: Por favor, ponga una X en la línea para indicar la gravedad que normalmente siente sus ojos secos y / o irritados Muy leve_______________________________________Muy Grave SANDE: Symptom Assessment iN Dry Eye Schaumberg DA et al. Development and Validation of a Short Global Dry Eye Symptom Index
The Ocular Surface 2007;5:50-57 Dry eye syndrome & Keratoconus
  • 16. Psicometría Escala Visual Analógica 1. Frecuencia de los síntomas: Por favor, ponga una X en la línea para indicar lo frecuente que normalmente siente sus ojos secos y / o irritados comparado con su visita de hace dos meses Raramente _______________________________________Siempre Ultima visita 2. Gravedad de los síntomas: Por favor, ponga una X en la línea para indicar la gravedad que normalmente siente sus ojos secos y / o irritados comparado con su visita de hace dos meses Muy leve_______________________________________Muy Grave Ultima Visita Schaumberg DA et al. Development and Validation of a Short Global Dry Eye Symptom Index
The Ocular Surface 2007;5:50-57 Dry eye syndrome & Keratoconus
  • 17. Treatment Multidisciplinary approach. Multiple and Protracted Avoid risk factors Scratch Contact lens Hygiene Preventive treatment Education of the patient Avoid tear evaporation Anti-inflammatory if evidence of inflammation Dry eye syndrome & Keratoconus
  • 18. Treatment Intra corneal ring segments Improvement of keratometry Reduction of dry eye symptoms Reduction of scratch Reduction of use of the contact lens Dry eye syndrome & Keratoconus
  • 19. Conclusions • Keratoconus patients are more susceptible to develop a dry eye syndrome • BUT & mucus thin layer healthy are good markers of a normal function of the epithelium of the ocular surface. • Treatment Protocol of DES in Keratoconus patients. Dry eye syndrome & Keratoconus